Dose
The standard dosage range for smoked 5-MeO-DMT is between 2-15 mg; for insufflation the dose range is 5-20 mg. These are very small amounts of material and should be measured extremely carefully. Many people achieve full world-shattering effects at as low as 3-5 mg (8-12 insufflated) and it is not uncommon for individuals who smoke 20-30 mg to have psychological and mental difficulties lasting several weeks.

Price
Occasionally sold at parties for 1-20 USD per dose. Available from exotic chemical suppliers for 150-250 USD per gram, somewhat higher from underground sources.

Law
5-MeO-DMT is unscheduled and uncontrolled in the United States, making it technically legal to possess. Sales or possession could be prosecuted under the Analog Act, although only one case of prosecution has been brought to our attention. We are not aware of any other country where it is specifically listed as illegal.

Chemistry
5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a naturally occurring chemical in the tryptamine class. It is related structurally to N,N-DMT, Bufotenine, Psilocybin, and Psilocin.

History
In the early 1950s, 5-MeO-DMT was identified as one of the main psychoactive ingredients in 'cohoba' snuffs used in the northern Amazon basin. Its use in the form of snuffs and brews has been documented as early as the 8th Century A.D. from a burial site in Northern Chile which found snuffing paraphernalia and traces of N,N-DMT, 5-MeO-DMT and Bufotenine. Other archeological sites have also uncovered seeds of 5-MeO-DMT containing Anadenanthera species from around the same time period. Its use as a recreational psychoactive has increased through the 80's and 90's.

Slang
The Substance: 5-MeO-DMT, 5-MeO
The Experience: the void

Onset
When smoked, 5-MeO-DMT generally reaches full effects within 10-60 seconds of inhalation. Insufflated, effects come in generally within 5 minutes.

Duration
The primary effects of 5-MeO-DMT last approximately 5-20 minutes when smoked, 30-45 minutes when insufflated. For many people there is an additional period of time (1-2 hrs) before fully returning to baseline. Some people find the 5-MeO-DMT experience difficult to integrate and experience unsettling thoughts and feelings for days after use.

The Experience

• The smoked 5-MeO-DMT experience is short, but generally incredibly intense. Onset is fast and furious, sometimes compared to being launched from a cannon. It is a fully engaging and enveloping experience of visions (actual visual effects less common) which varies greatly from one individual to the next. Users report profound changes in ontological perspective, experiencing the void, the shattering of the universe, frightening and overwhelming forces, complete shifts in perception and identity followed by an abrupt return to baseline. Because of the nature and intensity of the experience, users are almost always seated or lying down with someone nearby to take the pipe as the experience begins. Unlike with N,N-DMT, few users report significant coherent visual effects.
  
  
• The insufflated 5-MeO-DMT experience has a slower/gentler onset, with effects building over 20-45 minutes, and aftereffects lasting for 1-3 hours. Users report being better able to integrate the intensity and insights achieved from this method, with more clarity of thought, and time to explore those thoughts. As with the smoked method, dose response is extremely variable, and a heavy dose can be equally difficult, with aftereffects lasting hours or days.

Addiction Potential
5-MeO-DMT is neither physically addicting nor likely to cause psychological dependance. As with all substances, some people will use it more frequently than they are comfortable with. There is a short period of tolerance after 5-MeO-DMT use. Using 5-MeO-DMT a second time within a few hours is likely to lead to a significantly diminished experience the second time.

Contraindications

• The effects of smoked 5-MeO-DMT are dramatically increased if used by individuals currently taking MAOIs. MAOIs are most commonly found in the prescription anti-depressants Nardil (phenelzine), Parnate (tranylcypromine), Marplan (isocarboxazid), Eldepryl (l-deprenyl), and Aurorex or Manerix (moclobemide). Check with your doctor if you are not sure whether your prescription medication is an MAOI.
  
  
• Do not stand up. Do not operate heavy machinery. Do Not Drive.
  
  
• Individuals currently in the midst of emotional or psychological upheaval in their everyday lives should be careful about choosing to use psychedelics such as 5-MeO-DMT as they can trigger even more difficulty.
  
  
• Individuals with a family history of schizophrenia or early onset mental illness should be extremely careful because psychedelics have been known to trigger latent psychological and mental problems.